急性酒精中毒和慢性酒精使用增加了开放的骨骨折后感染的风险
Chirag Soni1, Elliott J Druten1, Michael Orcutt1
1Department of Orthopaedic Surgery.
Orthopedics
|December 3, 2025
概括
急性和慢性酒精使用增加了骨折相关感染 (FRI) 在开放的骨骨折的风险. 联合饮酒带来了复杂的风险,突出了对这一患者群体进行干预的必要性.
科学领域:
- 整形外科手术 整形外科手术
- 创伤护理 创伤护理
- 传染性疾病 传染性疾病
背景情况:
- 酒精消费是影响伤口愈合的已知的危险因素.
- 开放的骨骨折在骨科创伤护理中是一个重大挑战.
- 骨折相关感染 (FRI) 是骨科损伤后的一个严重并发症.
研究的目的:
- 调查急性和慢性酒精消费与骨折相关感染 (FRI) 发生率之间的关联,在患有开放骨骨折的患者中.
- 确定酒精使用是否会改变骨科创伤患者发展FRI的风险.
- 在酒精使用的背景下,确定有助于FRI的特定风险因素.
主要方法:
- 在一级创伤中心 (2017-2021) 接受治疗的骨成熟患者的骨骨折的回顾性评估.
- 包括标准要求六个月的随访和可用的血液毒理学结果.
- 在入院时以乙醇含量>10 mg/dL定义的急性酒精使用;根据每日消费或记录的历史记录的慢性酒精使用. FRI是主要结果,使用双变量和多变量方法进行分析.
主要成果:
- 在190个骨折中,有36.8%的骨折发生FRI (15个暗示性,55个确认性).
- 急性和慢性饮酒都与暗示性FRI独立相关 (分别为OR2.96和4.70).
- 同时的急性和慢性酒精使用显著增加了暗示FRI风险 (OR 11.05). 吸烟,隔间综合征和骨折严重程度增加了确认的FRI风险.
结论:
- 急性和慢性酒精使用是开放骨骨折中暗示骨折相关感染的重要危险因素.
- 急性和慢性酒精使用的联合存在加剧了暗示FRI的风险.
- 研究结果强调,需要针对骨科创伤中使用酒精的患者进行有针对性的干预,以减轻感染风险.
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