超软的水凝免疫毫米机器人具有多式联动机动
Zhiqiang Zheng1,2, Sinan Ozgun Demir2, Anping Wu3
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China.
Science advances
|December 3, 2025
概括
新的免疫千里机器人将细胞精确地传递给瘤. 这些可生物降解的机器人可以在复杂的环境中导航,并减少瘤生长,显示出对癌症治疗和免疫细胞输送的希望.
科学领域:
- 生物医学工程 生物医学工程
- 机器人技术 机器人技术 机器人技术
- 免疫治疗是一种免疫疗法.
背景情况:
- 细胞免疫疗法需要有效的免疫细胞传递系统.
- 目前的方法在精确准和导航复杂的生物环境方面面临挑战.
研究的目的:
- 开发基于水凝的先进免疫毫米机器人,以增强免疫细胞传递和瘤向.
- 为了研究机器人的运动,反应和治疗效果,在体外和体内.
主要方法:
- 制造嵌入磁性纳米粒子的超软水凝毫米机器人.
- 在对磁场和环境刺激 (离子,pH) 的反应中表现出适应性的运动 (行走,滚动,爬,波动).
- 对3D瘤模型的体外根除和小鼠体内瘤生长减少的评估.
主要成果:
- 米利机器人实现了高免疫细胞负载和精确的瘤向.
- 证明了多功能运动,可以在复杂的生物环境中导航,并与瘤形状保持一致.
- 在四天内成功根除了体外的3D瘤模型,并在15天内显著减少了体内瘤的生长.
- 通过生物发光成像,在瘤部位增强了自然杀手细胞活性.
- 显示出出色的生物相容性和生物降解性,没有观察到任何不良影响.
结论:
- 开发了一种灵敏,柔软的机器人系统,用于先进的免疫细胞输送.
- 毫米机器人显示出癌症治疗和研究瘤免疫动态的巨大潜力.
- 这项技术为向药物输送和癌症治疗提供了一种新的方法.
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