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甲状腺疾病对肠道微生物群的影响:新出现的机制和临床相关性

Isabela Busto Silva¹, Manuel Puig-Domingo²

¹Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, PR, Brasil.

Archives of endocrinology and metabolism

|December 3, 2025

概括

肠道微生物群影响甲状腺健康,与甲状腺疾病相关的不平衡. 针对肠道细菌的干预措施有望改善甲状腺功能和治疗结果.

科学领域:

内分泌学在内分泌学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

甲状腺-肠轴描述了肠道微生物群和甲状腺功能之间的相互作用.
肠道疾病越来越多地与各种甲状腺疾病有关,包括自身免疫性疾病,结节和癌症.
肠道微生物组影响免疫调节,代谢和甲状腺激素调节.

研究的目的:

审查当前对甲状腺-肠轴的理解.
探索肠道微生物群及其代谢物在甲状腺功能和疾病中的作用.
突出针对甲状腺疾病的肠道微生物群的潜在治疗策略.

主要方法:

文献综述综合了当前关于甲状腺肠轴的研究.
对研究肠道失调对甲状腺自身免疫,结节和癌症的影响的分析.
检查微生物代谢物和干预措施对甲状腺健康的影响.

主要成果:

肠道失生症通过增加肠道透性和免疫激活来加剧甲状腺自身免疫.
特定细菌的变化 (例如,减少短链脂肪酸生产者) 与甲状腺疾病有关.
微生物群影响必需营养物质 (,) 的生物可用性,并影响甲状腺癌治疗反应.
微生物代谢物,如托衍生物,在与甲状腺功能相关的免疫调节中发挥作用.

结论:

肠道微生物群及其代谢物显著影响甲状腺功能,无论是直接还是间接.
肠道功能失调是甲状腺疾病发展和进展的关键因素.
针对微生物组的干预措施为管理甲状腺疾病和提高治疗疗效提供了潜在的治疗策略.

关键词:

胃肠道的微生物群脂肪酸脂肪酸脂肪酸脂肪酸甲状腺疾病甲状腺疾病一个不稳定的波动性.

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