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降低PRC2功能会通过降低WNT通路活性导致T-ALL中阿斯巴拉金酶耐药性

Thomas Lefeivre1, Theodora-Ioana Grosu1, Cosmin Tudose1

  • 1University College Dublin, Dublin, Ireland.

Blood advances
|December 3, 2025
PubMed
概括

在T型急性淋巴细胞白血病 (T-ALL) 中,多抑制复合体2 (PRC2) 遗传因子的丧失通过改变WNT/STOP信号来降低阿斯巴拉金酶的敏感性. 蛋白质酶抑制可以克服这种耐药性,改善T-ALL治疗结果.

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