基线口腔微生物组与6个月内活体供体肝移植后早期并发症相关
Rosmy Babu1, Manjeet Kaur1, Shvetank Sharma2
1Department of Pathology, Institute of Liver and Biliary Sciences, D1, Vasant Kunj, New Delhi, India.
概括
肝硬化患者的口腔微生物组变化预测了肝移植后的并发症. 在基线时特定的细菌特征可以识别排斥,感染和胆道问题的风险,有助于非侵入性风险分层.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 口腔失调与肝硬化有关,可能会影响肝移植 (LT) 的结果.
- 了解口腔微生物组在LT后并发症中的作用对于改善患者管理至关重要.
研究的目的:
- 评估在LT之前的肝硬化接受者 (CRs) 的基线口腔微生物组.
- 研究LT前口腔微生物概况与LT后六个月内早期并发症 (ECs) 之间的关联.
主要方法:
- 对94个CR及其活体捐赠者的前性纵向研究.
- 使用细菌测序,qPCR和细胞因子分析分析LT前后的唾液样本.
- 监测LT后的EC,包括排斥,感染,胆道并发症 (BCs) 和死亡.
主要成果:
- 与捐赠者相比,CRs显示出不同的基线口腔微生物组,其中富含的Bacillota,Streptococcaceae和Veillonellaceae.
- 在基线时,特定的微生物特征与LT后的EC相关:Escherichia marmotae (排斥),Prevotella唾液 (感染),Rothia和Lactobacillus rhamnosus (BCs).
- 丰富Prevotella_7_sp2,Klebsiella pneumoniae和Staphylococcus与与败血症相关的死亡率相关;在口腔细菌和细胞因子之间观察到促炎联系.
结论:
- 基线口腔微生物组简介在患有后LTEC患者和不患有后LTEC患者之间有显著差异.
- 识别唾液中的特定微生物特征可能提供一种非侵入性方法,用于肝移植接受者的风险分层.
相关概念视频
01:28Kidney Transplant I: Introduction
310
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
310
01:26Kidney Transplant II: Surgical Procedure
289
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
289
01:16Kidney Transplant III: Nursing Management
294
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
294
01:22Bone Marrow Sampling and Transplants
829
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
829
01:24Tissue Transplantation
870
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
870