为出售性行为的年轻女性建立一个以药房为基础的暴露前预防计划:随机对照试验的协议
Oppah Kuguyo1, Helena Archer2, Lance Azizi2
1Department of Sexual and Reproductive Health, Centre for Sexual Health HIV/AIDS Research Zimbabwe, Harare, Zimbabwe.
JMIR research protocols
|December 3, 2025
概括
这项研究试行了Zimbabwe (TOPAZ) 的Together Optimizing PrEP Access (TOPAZ) 干预措施,为性工作者通过药房提供HIV暴露前预防 (PrEP) 补充. 这种以药房为基础的模式旨在改善PrEP的延续,并降低这一关键人群中的HIV风险.
科学领域:
- 公共卫生 公共卫生
- 预防艾滋病毒 预防艾滋病毒
- 实施科学 实施科学
背景情况:
- 性工作者 (SW) 面临艾滋病毒风险升高和预防措施的低采用,如暴露前预防 (PrEP).
- 加强PrEP可访问性和方便性的社区计划可以显著改善坚持并减少艾滋病毒传播.
研究的目的:
- 共同开发和试点Zimbabwe (TOPAZ) 的Together Optimizing PrEP Access干预措施,使SWs能够在药店获得PrEP补充.
- 评估基于药房的PrEP补充剂的可行性,可接受性和有效性,以改善SWs中的PrEP延续.
主要方法:
- 一种参与式的方法,涉及SW和药房所有者来设计TOPAZ干预措施,包括方便的补充提取器和激励措施.
- 一个集群随机试验试验比较基于药房的PrEP与基于诊所的标准取药,评估PrEP在多个时间点的保留.
- 混合方法研究,以评估实施结果 (可接受性,可行性等). 并为未来的扩展和有效性试验提供信息.
主要成果:
- 参与者招生于2024年3月开始,数据收集于2025年5月结束.
- 计划在2026年2月进行全面的数据分析.
- 该研究将提供关于PrEP保留和实施结果的初步数据.
结论:
- 托帕兹干预表明,通过可访问的药房补充,改善SWs中PrEP持续的有希望的策略.
- 成功的试点可能会导致更大的有效性试验,可能会改变对关键人群的艾滋病毒预防.
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