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Updated: Jan 9, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
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作为具有抗糖尿病作用的选择性TGR5激动剂的新 bis (((triazole) 类似物

Anchal Saxena1, Devanshu Kaushik2, Boda Arun Kumar2

  • 1Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P. 226031, India; Jawaharlal Nehru University (JNU), New Delhi 110067, India.

Bioorganic chemistry
|December 3, 2025
PubMed
概括

研究人员开发了用于治疗2型糖尿病和肥胖症的新型TGR5激动剂. 化合物7i在临床前研究中显示显著降低葡萄糖,抑制食欲和减少体重增加,显示出治疗潜力.

关键词:
胆酸受体激活剂胆酸受体激活剂双三) 的类似物.糖尿病 糖尿病 糖尿病通过GloSensor测试进行测试.肥胖问题 肥胖问题

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