SARS-CoV-2 变种对死产率的影响 - 来自 CRONOS 注册表的数据
Nora Schaumann1, Nadine Mand2, Tanja Groten3
1Institute of Pathology, Hannover Medical School, Carl-Neuberg-Straße 1, 30161, Hannover, Germany.
Placenta
|December 3, 2025
概括
COVID-19 Alpha和Delta变种通过引起胎盘炎症增加了死产风险. 欧米克朗和野生型的SARS-CoV-2没有显示这种关联,这表明变种对怀孕结果的特定影响.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 在COVID-19大流行期间,与SARS-CoV-2感染相关的死产报告增加.
- 需要了解死胎,胎盘变化和特定病毒变异之间的关联.
研究的目的:
- 评估SARS-CoV-2感染,胎盘病理和死产之间的关联.
- 确定特定的病毒变体 (野生型,阿尔法,三角形,欧米克朗) 是否会对死胎率和胎盘健康产生差异影响.
主要方法:
- 来自前性多中心CRONOS注册表 (COVID-19相关产科和新生儿结果研究) 的数据分析,涉及8032名感染SARS-CoV-2的孕妇.
- 排除染色体疾病或严重先天性缺陷的病例;详细收集死产病例的数据.
主要成果:
- 在7224个符合条件的怀孕中观察到0.6%的死胎率.
- 死亡出生率因变体而异:0.6% (野生型),1.6% (阿尔法型),0.8% (三角型) 和0.3% (欧米克朗型),具有显著的p值 (p=0.002).
- 在71%的与阿尔法和三角形变体相关的死产胎盘中发现了SARS-CoV-2胎盘炎,但在野生型或Omicron病例中没有.
结论:
- 阿尔法和三角形SARS-CoV-2变种显示病毒类型对胎盘有影响,可能导致死产.
- 在SARS-CoV-2感染期间,建议对胎儿进行有针对性的监测.
- 由于COVID-19而导致的死胎不太可能发生在感染后4周以上.
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