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Updated: Jan 9, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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用HepaSH单层预测人类肝脏清除,用于低周转率化合物

Shotaro Uehara1, Yuichiro Higuchi1, Nao Yoneda1

  • 1Liver Engineering Laboratory, Department of Research for Humanized Model, Central Institute for Experimental Medicine and Life Science, Kanagawa, Japan.

Drug metabolism and disposition: the biological fate of chemicals
|December 3, 2025
PubMed
概括

长期培养的高功能HepaSH细胞改善了药物清除预测. 这种稳定的体外系统准确地监测低周转率的化合物,有助于药物开发的药理动力学特征.

关键词:
肝炎SH 细胞 肝炎SH细胞预测肝脏清除时间肝细胞 肝细胞 肝细胞人性化的肝脏小鼠.低周转率的药物 低周转率的药物

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