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阴道神经刺激后的心情和认知负担在双重功能性发作患者

Vishva Natarajan¹, Ravi Sandhu¹, Charles Mazof¹

¹Geisel School of Medicine at Dartmouth, 1 Rope Ferry Rd, Hanover, NH 03755, United States of America.

Epilepsy & behavior : E&B

|December 3, 2025

概括

患有发作 (ES) 和功能性发作 (FS) 的患者在漫游神经刺激 (VNS) 治疗后出现了发作频率增加和抑郁症. 这凸显了对这种复杂的双重诊断群体进行仔细咨询和进一步研究的需要.

科学领域:

神经学神经学
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

发作 (ES) 和功能性发作 (FS) 的双重诊断提出了一个复杂的临床挑战.
迷你神经刺激 (VNS) 是一种成熟的耐火性治疗方法,但它对双重诊断的影响还未得到充分研究.
神经精神负担是ES和FS结合患者的一个重要问题.

研究的目的:

评估ES和FS双重诊断的患者的神经精神负担,这些患者已经接受了VNS.
将接受VNS的双重诊断患者的结果与ES患者和没有VNS的双重诊断患者的对照组进行比较.

主要方法:

对2015年至2024年期间接受VNS的双重ES和FS的成年患者的回顾性分析.
倾向性得分匹配以创建控制组:只有ES与VNS,以及没有VNS的双ES/FS.
纵向分析患者报告的结果,包括发作频率,抑郁症 (NDDI-E) 和认知生活质量 (QOLIE-31).

主要成果:

与没有VNS的患者相比,VNS的双重诊断患者报告的发作频率明显更高 (中位数为14.1比2.2,p=0.001).
双重ES/FS和VNS患者的抑郁症状明显大于仅ES患者的VNS患者 (NDDI-E中位数为16.4比8.8,p=0.015).
两组之间没有观察到认知生活质量的显著差异.

结论:

接受VNS的双重诊断患者经历了发作报告和抑郁负担的增加,这可能反映了潜在的并发症严重程度.
这些发现强调了在这个人群中对VNS进行彻底的植入前咨询的重要性.
需要使用基线评估进行前性研究,以更好地了解ES和FS结合患者的VNS结果.

关键词:

认知能力认知能力认知能力抑郁症抑郁症抑郁症是一种病.功能性发作功能性发作神经调节是一种神经调节.精神性非发作精神病发作松动神经刺激松动神经刺激

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