BRAF p.V600E在混合牙性瘤中的突变及其临床相关性:系统性审查和元分析
Soranun Chantarangsu1, Ekarat Phattarataratip1, Aroonwan Lam-Ubol2
1Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
International dental journal
|December 3, 2025
概括
这种BRAF p.V600E突变与乳腺瘤和乳腺纤维瘤有关,这表明它在瘤中起到了作用. 这种突变在牙瘤中没有发现,使这些瘤类型有所区别.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 混合牙致癌瘤的发病因子尚未完全理解.
- 在这些病变中BRAF p.V600E突变的作用需要澄清.
研究的目的:
- 为了确定BRAF p.V600E突变在各种混合性牙致癌瘤中的流行率.
- 评估BRAF突变与这些瘤的临床特征之间的相关性.
主要方法:
- 9项研究的系统综述和随机效应元分析.
- 在PubMed/MEDLINE,Embase和Scopus数据库中进行了搜索.
- 使用修改后的AHRQ尺度评估研究质量.
主要成果:
- BRAF突变的发病率:AFS (71.4%),AF (67.4%),AFO/AFD/DO (55.6%). 这种突变的发病率大约是1. 牙瘤 (OD) 没有突变.
- BRAF突变的病变 (AF,AFO/AFD/DO,AFS) 大于OD.
- AFS的复发率更高;BRAF突变的AF显示女性倾向.
结论:
- BRAF突变与阿美洛布拉斯纤维瘤,阿美洛布拉斯纤维牙瘤/阿美洛布拉斯纤维牙瘤/发育性牙瘤以及阿美洛布拉斯纤维肉瘤有关,但不是牙瘤.
- 在AFO/AFD/DO中存在BRAF突变,在某些情况下支持瘤性质.
- 需要进一步的研究来根据BRAF突变状态和临床相关性来区分这些实体.
关键词:
亚美洛布拉斯体纤维性口腔瘤亚美洛芽细胞纤维瘤亚美洛布拉斯细胞纤维肉瘤 (Ameloblastic Fibrosarcoma) 是一种细胞瘤.在 BRAF p.V600E 中.牙造成的肉瘤 (Odontogenic sarcoma) 是一种牙造成的肉瘤.耳鼻瘤 (odontoma) 是一种耳鼻瘤.更多相关视频
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