对转录组学和蛋白质组学的综合分析揭示了加工的奥克兰菌根对功能性消化不良的改善作用
Ruiyin Ye1, Shuting Zhai1, Shaoxuan Li1
1Jiangxi University of Chinese Medicine, Nanchang, 330004, China.
Journal of ethnopharmacology
|December 3, 2025
概括
经过加工的奥克兰草根 (WMX) 通过调节肠道和通过NOD1/RIPK2/ERK通路减少炎症来改善功能性消化不良 (FD). 这项研究澄清了WMX.
科学领域:
- 胃肠病学和药理学 胃肠病学和药理学
- 传统中国医药 传统中国医药
- 系统生物学 系统生物学
背景情况:
- 经过加工的奥克兰菌根 (WMX) 传统上用于胃肠道疾病.
- 它在功能性消化不良 (FD) 中关于肠道运动性的机制尚不清楚.
- 这项研究调查了WMX对FD的影响.
研究的目的:
- 评估WMX在FD小鼠模型上的治疗效果.
- 通过综合转录组和蛋白组分析阐明底层机制.
- 探索WMX对脑肠和炎症通路的影响.
主要方法:
- 使用酸胺 (IAA) 建立了一种FD小鼠模型.
- 通过测量胃排空,肠道推进和血清脑肠 (MTL,Gastrin,GHRP-Ghrelin,VIP,SS,CCK) 来评估WMX的疗效.
- 综合转录组和蛋白组分析确定了关键的信号通路,通过RT-qPCR和西式涂抹进行验证.
主要成果:
- WMX显著改善了FD症状,增强了胃排空和肠道推进,并减少了胃炎症.
- WMX使失调的脑肠水平正常化,激发性的增加和抑制性的减少.
- 综合分析强调了NOD类受体信号通路,WMX降低了NOD1,RIPK2,ERK,IL-6,TNF-α和IL-18.
结论:
- 通过调节脑肠水平,WMX可以改善FD.
- WMX可以抑制NOD1/RIPK2/ERK信号通路介导的过度炎症.
- 这项研究提供了对WMX对FD治疗效果的机制性见解.
关键词:
改善的效果 改善效果脑肠是脑肠的一种.功能性消化不良症 功能性消化不良症经过加工的奥克兰地亚菌根 (Aucklandiae radix).蛋白质组学是指蛋白质组学.文字转录学 (Transcriptomics) 是一个学科.更多相关视频
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