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武威甘露通过线粒体强化和氧化还原-炎症调节来抵消运动引起的疲劳

Can Tang¹, Shuhao Zhang¹, Dingzeng Nima²

¹State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.

Journal of ethnopharmacology

|December 3, 2025

概括

武威甘露 (WGL) 浴通过增强线粒体功能和减少炎症来对抗运动引起的疲劳. 这种传统的西藏配方可以提高耐力和肌肉健康,支持它的历史用途.

科学领域:

综合医学和药理学综合医学和药理学
运动生理学和生物化学
传统的西藏医学传统的西藏医学

背景情况:

武威甘露 (WGL) 是西藏医药浴配方,传统上用于关节硬和胀.
它对运动引起的疲劳和潜在机制的有效性尚不清楚.

研究的目的:

评估WGL的抗疲劳活性.
探索涉及WGL效应的线粒体和氧化还原炎症机制.

主要方法:

使用UPLC-Q-Orbitrap-MS/MS分析了WGL的组成部分.
网络药理学确定了关键的线粒体和炎症点.
昆明小鼠接受了为期14天的加重强迫游泳测试,每天进行WGL浴.

主要成果:

WGL含有黄酸,酸和酸;网络药理学强调AKT1,PIK3CA和TGFB1作为主要点.
使用WGL显著增加了耐力,减少了肌肉损伤的标志物 (BUN,CK,LDH,MDA) 和减少了促炎细胞因子 (IL-1β,TNF-α).
WGL恢复了被抑制的乌比金生物合成中间体,并增加了Coq7mRNA的表达,表明线粒体功能得到改善.

结论:

通过涉及Coenzyme Q (CoQ) 相关的线粒体功能机制,WGL有效地应对运动引起的疲劳.
WGL重新平衡了氧化还原-炎症信号通路,为其传统的外部应用提供了科学支持.
这些发现表明,WGL具有作为抗疲劳干预措施进一步发展的潜力.

关键词:

运动引起的疲劳.炎症信号传递是炎症信号.氧化应激是一种氧化应激.乌比金的生物合成武威是没有的.

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