社会焦虑障碍中的白物质微观结构变化:ENIGMA焦虑工作组的12个队列的大型分析
Eline F Roelofs1, Nynke A Groenewold2, Kinga Farkas3
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, the Netherlands.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|December 3, 2025
概括
社会焦虑障碍 (SAD) 与白质 (WM) 微观结构的差异有关,特别是在体和体. 在患有SAD的个体中,WM通道中的这些神经生物学变化可能因年龄和性别而异.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 关于社会焦虑障碍 (SAD) 中白质 (WM) 微观结构的改变存在不一致的发现.
- 埃尼格玛焦虑工作组进行了一项大规模的元分析,以调查SAD中的WM差异.
研究的目的:
- 为了比较患有SAD和健康对照 (HC) 个体之间的WM微观结构.
- 探索SAD组内的WM差异中的年龄和性别变化.
主要方法:
- 扩散张力成像数据的大型分析来自487名SAD患者和1604名HC参与者 (8-65岁).
- 使用标准化的ENIGMA协议,专注于分数异构性 (FA) 作为主要的WM微观结构测量.
- 线性混合效应模型分析了差异,对成人和青少年子组进行了单独的分析.
主要成果:
- 与HC相比,患有SAD的个体在体和体等航道中表现出较低的FA.
- 通过诊断发现了显著的性别相互作用,主要在SAD的女性中较低的FA.
- 患有SAD的成年人表现出广泛的较低FA,而青少年则表现出年龄对诊断的相互作用.
结论:
- 这项超级分析确定了SAD和HC患者之间WM微观结构的显著差异.
- 与SAD相关的WM通道的神经生物学变化似乎受到年龄和性别的影响.
- 研究结果表明,潜在的超诊断性神经生物学特征是SAD心理病理的基础.
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