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穿皮气球压缩通过神经炎症和神经递质调节在三神经疼痛中表现出多维的有效性

Yihui Du¹, Haowei Shi¹, Zenghui Xi¹

¹Department of Neurosurgery, Hebei General Hospital, Shijiazhuang 050000, China.

World neurosurgery

|December 3, 2025

概括

穿皮气球压缩 (PBC) 与药物治疗相比,为三角神经疼痛 (TN) 患者提供更好的疼痛缓解和改善生活质量. 此外,PBC还有效地减少了与TN相关的神经炎症和心理痛苦.

科学领域:

神经学神经学
疼痛管理疼痛管理
精神病学是一个精神病学.

背景情况:

三神经疼痛 (TN) 是一种衰弱的疾病,其特征是严重的面部疼痛.
心理并发症和神经炎症是TN影响患者结果的重要方面.
目前对TN的治疗选择在解决其多维性质方面存在局限性.

研究的目的:

评估皮肤穿气球压缩 (PBC) 在治疗三角神经疼痛 (TN) 的现实有效性.
评估PBC对减轻疼痛,心理困扰,生活质量 (QoL) 和神经炎症标志物的影响.
为了比较PBC结果与TN的标准药物治疗,TN.

主要方法:

对140名TN患者的回顾性分析,将68名接受PBC的患者与72名接受药物治疗的患者进行比较.
倾向性得分匹配创建了57对可比对来进行可靠的分析.
测量结果包括视觉模拟尺度 (VAS) 疼痛,汉密尔顿尺度 (HAMD/HAMA) 抑郁/焦虑,SF-36 QoL,以及血清生物标志物 (5-HT,物质P,IL-1β,TNF-α).
差异差异 (DID) 和概括估计方程 (GEE) 用于统计分析.

主要成果:

与药物治疗相比,PBC表现出明显优异的疼痛缓解 (VAS减轻) 和QOL改善 (SF-36得分) (p <0.05).
PBC治疗导致抑郁症 (HAMD) 和焦虑症 (HAMA) 症状显著减少.
在接受PBC治疗的患者中,生物标志物分析显示5-HT,P物质,IL-1β和TNF-α的显著降低 (p <0.01).
整体疗效在PBC (98.08%) 和对照组 (84.62%) 中较高,并发症较少.

结论:

穿皮气球压缩 (PBC) 为三角神经疼痛 (TN) 提供了超越简单止痛的综合益处.
在TN患者中,PBC有效地减轻情绪障碍,并使神经炎症信号正常化.
这些发现支持PBC在调节疼痛-神经免疫轴的作用,用于TN的综合神经精神病学管理.

关键词:

差异中的差异模型情绪障碍情绪障碍情绪障碍炎症因素炎症因素通过皮肤进行的气球压缩.倾向性得分匹配的匹配方法三叉子神经疼痛三叉子神经疼痛

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