相关实验视频

Updated: May 4, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

可注射的奇托桑/马尔托德克斯/微晶纤维素水凝,含有黑色素,用于椎间盘再生

Büşra Nur Yeşilyurt¹, Mustafa Nakipoğlu², Ayşen Tezcaner³

¹Department of Biomedical Engineering, Middle East Technical University, Ankara, Turkey.

International journal of biological macromolecules

|December 3, 2025

概括

这项研究开发了一种可注射的黑激素装载水凝,使用奇托,氧化马尔托德克斯和氧化微晶纤维素来进行椎间盘再生. 这种新型的水凝增强了细胞增殖和甘氨酸甘氨酸合成,显示出治疗磁盘变性治疗的前景.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
整形外科整形外科整形外科

背景情况:

椎间盘退化是一种普遍存在的疾病,其再生能力有限.
目前对磁盘退化的治疗主要是治疗症状,而不是恢复功能.
可以注射的水凝正在成为脊椎间盘再生的有希望的治疗策略.

研究的目的:

开发和描述一个可注射的黑激素载荷的水凝用于椎间盘再生.
评估氧化微晶纤维素 (ox-MCC) 对水凝特性和性能的影响.
评估含有黑激素的水凝的生物相容性和治疗潜力,使用细胞核.

主要方法:

制造一种可注射的凝复合物,由奇托 (CS),氧化马尔托德 (ox-MD) 和氧化微晶纤维素 (ox-MCC) 制成.
水凝性质的表征,包括凝时间,降解,机械强度 (斯模量) 和氨酸释放动力学.
在体外评估水凝细胞毒性,细胞增殖和使用牛核肉质 (NP) 细胞合成糖氨酸甘氨酸.

主要成果:

加入ox-MCC显著减少了凝时间,并在降解过程中改善了水凝重量保留.
增加ox-MCC含量增强了水凝的机械性能,Young的模量增加了六倍.
含有 Melatonin 的水凝显示出无毒性,支持 NP 细胞增殖,并显著增加了糖氨酸甘氨酸合成,在含有 Melatonin 的配方中观察到的最高水平.

结论:

开发的注射性黑激素充满凝,包括ox-MCC,表现出有利的物理化学和机械性能.
液凝配方是生物相容的,有效地促进细胞核的细胞增殖和细胞外基质合成.
这种含有黑色素的水凝具有作为治疗椎间盘再生的治疗剂的巨大潜力.

关键词:

软骨组织工程软骨组织工程基托桑是一种酸盐.可以注射的水凝.椎间盘 (IVD) 的再生马尔托德克斯特林 (Maltodextrin) 是一种葡萄糖.黑色素是什么黑色素是什么黑色素是什么微晶纤维素的微晶纤维素.它的核心是脉的.

更多相关视频

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

相关概念视频

Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...