社会人口统计学和医疗保健因素与随机临床试验的招生有关,该试验将戒烟与肺癌查相结合
Efrén J Flores1, Caylin Marotta2, Yuchiao Chang2
1Health Promotion and Resiliency and Intervention Research Program, Mongan Institute Health Policy Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; MGB Radiology Vice Chair, Faculty & Trainee Enrichment; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; JACR Associate Editor for Health Equity.
这项研究发现,年龄较大,女性性别,非西班牙裔黑人,拥有大学学位和较少的初级保健访问增加了参加肺癌查烟草戒烟试验的人数. 将试验整合到临床途径中可能会改善公平性和结果.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 临床试验 临床试验
背景情况:
- 肺癌查 (LCS) 识别了患肺癌高风险的个体.
- 戒烟干预对于经历LCS的人来说至关重要.
- 了解影响临床试验招生因素是改善参与和结果的关键.
研究的目的:
- 评估与参加"屏幕辅助"禁烟随机对照试验相关的社会人口统计和医疗保健因素.
- 确定符合LCS资格的个人参与的预测因素.
主要方法:
- 使用电子健康记录和区域贫困指数 (ADI) 的回顾性研究.
- 包括符合2019年4月至2023年7月11个地点的屏幕辅助资格的个人.
- 单变量和逻辑回归分析评估了因子和试验招生之间的关联.
主要成果:
- 在4090名符合条件的个人中,15.7% (642) 参与了试验.
- 在注册和未注册组之间,年龄,ADI或查尔森并发症指数没有显著差异.
- 与70岁以上的年龄,女性性别,非西班牙裔黑人种族,大学学位和过去一年零次初级保健访问相关的更高的入学概率.
结论:
- 经常与参与率较低相关的因素显示,在这个LCS集成的戒烟试验中,招生可能性增加.
- 将临床试验招聘纳入现有临床途径可以提高参与中的公平性.
- 这种方法为改善与烟草有关的健康结果和LCS吸收提供了机会.
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