与心血管疾病和美国西班牙裔和拉丁裔的全因死亡率
Alexandrina Danilov1, Priscilla Duran-Luciano1, Yawen Yuan1
1Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, USA.
Journal of the American College of Cardiology
|December 3, 2025
概括
升高的脂蛋白[Lp[a]水平增加了西班牙裔/拉丁裔成年人的心血管疾病风险. 值≥125nmol/L是一个有效的指标,但风险随着Lp (a) 的水平不断增加.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 脂蛋白 (Lp) 是动脉样硬化心血管疾病的已知危险因素.
- 一个≥125nmol/L的共同值可以识别高风险个体,但针对西班牙裔/拉丁裔人口的具体数据是有限的.
研究的目的:
- 综合评估Lp(a) 水平及其与美国西班牙裔/拉丁裔成年人10年心血管疾病风险和死亡率的相关性.
- 在这个人口群体中评估≥125nmol/L Lp (a) 值的实用性.
主要方法:
- 来自西班牙裔社区健康研究/拉丁裔研究的16117名参与者的分析.
- 评估Lp(a) 水平 (五分位数,日志转换和≥125nmol/L值) 与心肌梗塞,缺血性中风和全因死亡率之间的关联.
- 利用多变量Cox比例危险模型和采样权重来考虑队列设计.
主要成果:
- 平均Lp (a) 是19.7nmol/L,其中11.4%的参与者Lp (a) ≥125nmol/L.
- 升高的Lp (a) ≥125nmol/L与心肌梗塞的风险增加有关 (HR:2.29) 和所有原因的死亡率 (HR:1.43).
- 在增加的Lp (a) 水平和心肌梗塞风险之间观察到持续的关系.
结论:
- 拉丁裔/拉丁裔Lp升高的人面临心肌梗塞和全因死亡的风险较高.
- 这种人群适用于≥125nmol/L Lp (a) 值.
- 在西班牙裔/拉丁裔人群中,对心血管疾病的风险评估应考虑Lp (a) 水平与风险之间的持续关系.
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