在接受脏移植的接受者中,JC多聚马病毒相关的脏病
Wouter T Moest1, Joris I Rotmans2, Gijs Fortrie3
1Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands w.t.moest@lumc.nl.
BMJ case reports
|December 3, 2025
概括
在一个移植接受者中诊断出JC多瘤病毒 (JCPyV) 病,其移植功能下降. 这一案例凸显了在移植患者中考虑JCPyV的重要性,即使怀疑但未检测到BK多种瘤病毒.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 病毒病原体的产生
背景情况:
- 移植是末期病的救生治疗方法.
- 机会性病毒感染可能会威胁到长期的移植生存.
- 杰克多瘤病毒 (JCPyV) 是移植受体脏病的未被认可的原因.
研究的目的:
- 在移植接受者中报告JC多重瘤病毒病例.
- 强调JCPyV感染移植后的诊断挑战和临床影响.
主要方法:
- 一个病人的病例报告进行了捐赠-循环-死后-移植.
- 评估衰退的移植功能,包括脏活检和免疫组织化学.
- 定量PCR (qPCR) 用于在血和组织中检测BK多元瘤病毒 (BKPyV) 和JC多元瘤病毒 (JCPyV).
主要成果:
- 患者患有慢性活跃的管间膜性炎.
- 没有检测到BKPyV,但通过QPCR在血和活检中确认了JCPyV.
- 尽管免疫抑制减少,但移植功能继续下降.
结论:
- 在移植患者中,移植功能下降时,应考虑JC多瘤病毒脏病,特别是当BCPyV测试呈阴性时.
- 提高临床意识和对JCPyV病原和管理的进一步研究至关重要.
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