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[多发性骨髓瘤中高风险细胞遗传异常的预后值]

X X Shen¹, J P Yu¹, R Guo¹

¹Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

|December 3, 2025

概括

在新诊断的多发性骨髓瘤 (NDMM) 患者中,mSMART 4.0系统提供了更精确的高风险细胞遗传异常 (HRCAs) 定义. 与mSMART 3.0.0相比,该系统可以更好地区分预后风险.

科学领域:

血液学血液学血液学
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

多发性骨髓瘤 (MM) 是一种由遗传复杂性为特征的血液性恶性瘤.
准确的风险分层对于优化新诊断多发性骨髓瘤 (NDMM) 患者的治疗策略至关重要.
细胞遗传异常在MM的预后中起着重要作用.

研究的目的:

在使用mSMART 3.0和mSMART 4.0风险分层系统的NDMM患者中,比较高风险细胞遗传异常 (HRCAs) 的预后值.
评估HRCA定义的准确性和两种mSMART版本之间的风险差异化.

主要方法:

从465名新诊断的多发性骨髓瘤患者的临床数据进行了回顾性分析.
根据mSMART 3.0和mSMART 4.0风险分层系统对患者进行了分层.
在每个分层系统中评估了HRCAs的预测值.

主要成果:

无论是mSMART 3.0还是mSMART 4.0系统,高风险患者的预后都比标准风险患者差.
增加的HRCA数量与NDMM的预后较差相关.
该mSMART 4.0系统提供了更精确的HRCA定义,考虑到共存的异常,并展示了优越的风险差异化能力.

结论:

mSMART 4.0风险分层系统为NDMM患者的HRCAs定义提供了更高的精度.
mSMART 4.0在区分细胞遗传风险类别方面表现出卓越的能力,导致更准确的预后评估.
这些发现支持采用mSMART 4.0来加强NDMM的风险分层和个性化治疗规划.

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