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不知初级的HPV相关的盆腔状细胞癌:两个案例研究

Sepideh Soltani¹, Sahar Dashti¹, Maryam Garousi¹

¹Department Of Radiation Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Cancer reports (Hoboken, N.J.)

|December 3, 2025

概括

人类乳头瘤病毒 (HPV) 基因型16在两例未知初级的骨盆状细胞癌 (SCC) 病例中被检测到. 这一发现表明,HPV可能表明这种罕见的癌症的预后更好.

科学领域:

在瘤学瘤学.
病毒学病毒学
病理学病理学病理学

背景情况:

未知原发性癌症 (CUP) 带来了重大的诊断和管理挑战.
原发性不明的盆腔状细胞癌 (SCC) 是CUP的一个罕见子组.
人类乳头瘤病毒 (HPV) 被认为是SCC的预后生物标志物,通常与改善的结果相关.

研究的目的:

报告两个原始来源不明的盆腔SCC病例.
调查HPV在这些病例中的作用.
探索HPV在未知初级的盆腔SCC中的潜在预后影响.

主要方法:

关于两名被诊断患有未知初级骨盆SCC的患者的病例报告.
在瘤样本上进行的HPV基因型鉴定.
分析了包括治疗反应和随访在内的临床数据.

主要成果:

这两种病例均为HPV基因型16的阳性测试.
案例1:一位54岁的女性,骨盆质量为11厘米,尽管接受了化疗,但疾病进展.
案例2:一名46岁的女性,骨盆质量为8厘米,对化疗和化疗放射治疗取得了完全的反应,没有复发.

结论:

未知初级的HPV相关的盆腔SCC呈现出诊断复杂性和治疗机会.
在这些病例中检测到HPV基因型16的证据支持了潜在的良好的预后.
需要进一步的研究,以阐明HPV在指导管理策略中的作用,用于未知初级的盆腔SCC的管理策略.

关键词:

这是一个HPVHPVHPV.不知原因的原发性癌症.骨盆腔中的骨盆腔.状细胞癌的癌症.

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