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相关概念视频

Proteomics01:33

Proteomics

9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Networks02:26

Protein Networks

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Protein-Protein Interfaces02:04

Protein-Protein Interfaces

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Protein and Protein Structures02:15

Protein and Protein Structures

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相关实验视频

Updated: Jan 9, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

Published on: April 11, 2019

13.3K

ProteoformDB:一个内置的应用程序来生成Proteoform数据库.

Trung Hoàng1, Yingwei Hu1, Hui Zhang1

  • 1Department of Pathology, Oncology, Urology, and Chemical and Biomolecule Engineering, Johns Hopkins University, Baltimore, Maryland 21231, United States.

Journal of proteome research
|December 3, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了ProteoformDB,用于编目超过一百万个人类蛋白质. 该数据库通过记录实验识别的蛋白质形式,有助于理解蛋白质功能和疾病机制.

关键词:
国家数据库搜索策略 MS数据库搜索策略组合性的PTMs可以使用.联合量化量化情况基于质谱的蛋白质组学.多站点蛋白质形式的多站点蛋白质.蛋白质形式的注释蛋白形生物学的生物学蛋白质形状的特征表征蛋白质形式DBDB的定量化的蛋白质组学.

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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

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相关实验视频

Last Updated: Jan 9, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames

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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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科学领域:

  • 分子生物学分子生物学
  • 蛋白质组学是指蛋白质组学
  • 生物信息学是一种生物信息学.

背景情况:

  • 蛋白质对于细胞功能至关重要,其复杂性源于通过各种生物过程产生的多种蛋白质形式.
  • 了解蛋白形是解读生物通路和疾病发病过程中的蛋白质作用的关键.

研究的目的:

  • 开发一个应用工具,ProteoformDB,用于生成全面的proteoform数据库.
  • 为了研究用途,编目大量独特的人类蛋白质形式.

主要方法:

  • 开发用于数据库生成的ProteoformDB应用程序.
  • 编目超过一百万个独特的单位人类蛋白质形式的目录.

主要成果:

  • 成功创建和人口的ProteoformDB与超过一百万的人类蛋白形.
  • 展示ProteoformDB的实用性,作为一个资源,用于记录实验识别的蛋白形状.

结论:

  • 蛋白形DB作为一种有价值的资源,用于定量蛋白质组学中蛋白质的表征.
  • 该数据库支持对总蛋白质丰度和改性蛋白质形式的分析,推进蛋白质组研究.