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Updated: Jan 9, 2026

Capturing Chromosome Conformation Across Length Scales
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使用DAF-seq绘制单细胞双质染色体纤维架构的映射

Elliott G Swanson1, Yizi Mao2, Benjamin J Mallory1

  • 1Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Nature biotechnology
|December 3, 2025
PubMed
概括

一种新方法,Deaminase-Assisted单分子染色体纤维测序 (DAF-seq),绘制了染色体纤维上的蛋白质共占地. 这种技术揭示了单个细胞内和单个细胞之间以及跨类型的显著基因调节可塑性.

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
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Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
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