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在新皮层中调整前代平衡和上层神经元的产生

Cristine R Casingal1,2, Naoki Nakagawa1,2,3, Keiko Yabuno-Nakagawa1,2

  • 1UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Nature
|December 3, 2025
PubMed
概括

结核硬化综合体 (TSC) 蛋白调节原生平衡,影响上层神经元的产生. 人类中TSC蛋白的下调可能解释了对复杂大脑功能至关重要的神经元数量扩大.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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