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Updated: Jan 9, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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蛋白激酶A和组装一个ABCC4蛋白质网络

Jingwen Zhu1, Sabina Ranjit1, Tomoka Gose1

  • 1Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature communications
|December 3, 2025
PubMed
概括

研究人员发现了一种依赖于PDZ的蛋白质复合物,该复合物在细胞表面稳定了ABCC4载体,优化了循环AMP (cAMP) 流量和药物耐药性. 这一发现澄清了空间限制信号背后的机制.

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