相关实验视频

Updated: Jan 9, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

858

ApoA1驱动的胆固醇外流和巨细胞两极分化协调T细胞分化,以控制Leishmania donovani的病变发生

Vikash Kumar1, Dayakar Alti2, Shobha Kumari1

  • 1Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Science, Patna, 800007, India.

Scientific reports
|December 3, 2025
PubMed
概括

脂蛋白A1 (ApoA1) 缺乏与莱什曼病有关. ApoA1 增强胆固醇排放,减少寄生虫感染,促进抗莱什曼病免疫反应,这表明 ApoA1 是治疗点.

关键词:
莱什曼尼亚的捐赠人亚脂蛋白 A1 是一种阿波利波蛋白.胆固醇的排放流出.人类的PBMCs.在M1-巨细胞中.在 Th1 两极分化.

更多相关视频

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line06:38

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line

Published on: August 2, 2021

31.1K
Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites10:01

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites

Published on: March 16, 2018

10.9K

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
83.3K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.8K