泰尔米沙坦降低了全身炎症,并在轻度的COVID-19中改变了氨酸- ангиотензин系统
Angela Lu1, Melissa Agsalda-Garcia2, Weiyuan Hu1
1Titus Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA.
Scientific reports
|December 3, 2025
概括
泰尔米沙坦 (TEM) 是一种血管激素受体抑制剂,通过激活COVID-19患者有益的ACE2/Ang(1-7) /MasR通路来减少炎症和SARS-CoV-2病毒载量.
科学领域:
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于COVID-19通过降低ACE2的调节来破坏氨酸-血管氨系统 (RAS),导致炎症促成的 ангиотензин II (AngII) 的增加.
- 这种不平衡促进了SARS-CoV-2感染个体的肺炎.
研究的目的:
- 调查特尔米萨坦 (TEM) 是否是一种血管激素受体阻断剂 (ARB),可以减轻COVID-19相关的RAS失调.
- 评估TEM对COVID-19患者炎症和病毒载荷的影响.
主要方法:
- 一个随机,双盲,安慰剂控制的试点临床试验,涉及门诊SARS-CoV-2参与者.
- 参与者每天接受40毫克TEM或安慰剂.
- 用TEM治疗的A549-ACE2肺上皮细胞的体外分析.
主要成果:
- 在患者中,TEM治疗减少了全身炎症,并增加了MasR表达.
- 在体外,TEM增加了ACE2和MasR,同时降低了AT1R和AT2R的表达.
- 经过TEM治疗,AngII水平降低,Ang1-9) 和Ang1-7) 水平增加.
- 从生理学上相关的TEM度降低了SARS-CoV-2病毒载量.
结论:
- 泰尔米沙坦激活了COVID-19中的抗炎Ang(1-7) /MasR/ACE2通路.
- 泰米减轻了COVID-19诱导的RAS变化,减少了炎症和病毒载量.
- 这些发现支持像TEM这样的ARB来管理COVID-19.
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