在中年和老年人中,估计的葡萄糖处置率和肉症之间的关系
Yan Chen1, Lingli Gao1, Xiaolei Song1
1Rehabilitation Center, The First Affiliated Hospital of Henan University of Chinese Medicine, No.19 Renmin Road, Jinshui District, Zhengzhou, 450003, Henan Province, China.
Scientific reports
|December 3, 2025
概括
较低的估计葡萄糖处置率 (eGDR) 与老年人肉症风险增加有关. 这种胰岛素耐药性标志物显示出显著的预测能力,用于识别高风险个体.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肌肉质量和功能的与年龄相关的损失萨尔科佩尼亚,对中老年人和老年人来说是一个重大的健康挑战.
- 估计的葡萄糖处置率 (eGDR),胰岛素抵抗的标志物,和肉症风险之间的关联是不确定的.
研究的目的:
- 在中年和老年人中调查eGDR和肉症之间的关系.
- 评估eGDR对肉症风险的预测价值.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) (2011-2015) 数据的分析.
- 用物流和考克斯回归模型,受限立方线 (RCS) 和子组分析来评估关联.
- 接收器操作特征 (ROC) 曲线和机器学习模型评估了预测能力.
主要成果:
- 分析了1627名参与者的队列.
- 与较高的eGDR (>10.89) 相比,具有较低eGDR (<6.99) 的参与者表现出较高的麻症风险,特别是64岁以上和糖尿病患者.
- RCS分析显示,eGDR和低于eGDR<7.319的肉症风险之间存在显著的负非线性关系.
- 一个随机的森林模型确定了eGDR作为最关键的预测因素.
结论:
- 在老年人中,eGDR显示与肉症风险有显著的关联.
- eGDR具有强大的预测能力,可以识别患有沙科佩尼亚风险的个体.
- 这些发现凸显了代谢健康,特别是胰岛素耐药性在沙科佩尼亚发展中的潜在作用.
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