饮食中的植物化学物质摄入量和儿童的喘:一个病例控制研究
Renpeng Jiang1, Weihong Liu1, Guangjun Wang2
1Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China.
European journal of pediatrics
|December 3, 2025
概括
富含植物化学物质的饮食,以饮食植物化学指数 (DPI) 衡量,与降低喘风险和儿童改善结果有关. 较高的DPI与较低的炎症和更好的喘控制有关.
科学领域:
- 儿科过敏和免疫学
- 营养科学 营养科学
- 炎症性疾病研究的研究.
背景情况:
- 饮食模式通过抗炎和抗氧化机制影响喘风险和严重程度.
- 植物化学物质具有抗氧化和免疫调节特性,有利于治疗儿童喘.
- 饮食植物化学指数 (DPI) 量化了富含植物化学物质的食物的摄入量.
研究的目的:
- 调查饮食生化指数 (DPI) 与儿童喘相关结果之间的关联.
- 评估DPI与喘严重程度,控制,生活质量和炎症标志物之间的关系.
- 为了确定较高的DPI摄入量是否与小儿喘发病率较低有关.
主要方法:
- 一项涉及300名5至12岁儿童 (150名喘患者,150名对照患者) 的病例控制研究.
- 评估饮食摄入量使用经过验证的食物频率问卷来计算DPI.
- 通过儿科喘严重性评分 (PASS),儿童喘控制测试 (C-ACT),儿科喘生活质量问卷 (PAQLQ) 和血清C反应蛋白 (CRP) 测量临床结果.
主要成果:
- 与最低的三分之一相比,DPI最高的儿童的CRP水平显著降低,PAQLQ得分更高,PASS得分更低,C-ACT得分更高.
- 增加的DPI与减少炎症 (较低的CRP),改善生活质量 (较高的PAQLQ),降低喘严重程度 (较低的PASS) 和增强喘控制 (较高的C-ACT) 显著相关.
- 最高的DPI三位数与患喘的几率大幅降低有关,即使经过调整以考虑混因素.
结论:
- 更多的富含植物化学物质的食物消费,如较高的DPI所示,与儿童喘的可能性降低有关.
- 较高的DPI摄入量与较低的全身炎症相关,并且在患有喘的儿童中改善了临床结果.
- 这项研究强调了饮食的潜在作用,特别是植物化学品的摄入,在预防和治疗儿科喘.
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