根据遗传倾向优先考虑动脉样硬化心血管疾病的获得风险因素:对精确预防的含义
Ruiqi Zhang1, Boyang Xiang2, Yujia Zhou3
1Department of Radiology, Kunshan Hospital Affiliated to Jiangsu University, No. 566 Qianjin East Road,, 215300, Kunshan, P. R. China.
BMC cardiovascular disorders
|December 3, 2025
概括
获得的风险因素对动脉样硬化心血管疾病 (ASCVD) 有显著的贡献,心脏代谢因素是所有遗传风险组的主要原因. 根据遗传倾向量身定制预防策略可以提高ASCVD风险降低.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是全球主要的死亡原因.
- 了解所获得的风险因素如何与遗传倾向相互作用,对于有效的预防至关重要.
研究的目的:
- 调查25个获得的ASCVD风险因子的人口归因分数 (PAFs).
- 分析不同基因风险层 (低,中等,高) 的这些贡献.
主要方法:
- 利用了来自430,191名参与者 (40-69岁) 的英国生物库数据.
- 评估了25个获得的风险因素,包括社会经济,心理社会,生活方式,心脏代谢和临床因素.
- 在遗传风险组内计算冠状动脉疾病 (CAD),缺血性中风 (IS) 和外周动脉疾病 (PAD) 的PAF.
主要成果:
- 心脏代谢因素是所有遗传风险组中ASCVD发病率的主要贡献者,高血压占主导地位.
- 社会经济决定因素,特别是较低的教育水平,对ASCVD产生了重大贡献,尤其是在较低遗传风险群体中.
- 心理社会因素对ASCVD风险的影响随着遗传风险的增加而减少.
结论:
- 遗传倾向改变了获得的风险因素对ASCVD的影响.
- 个性化ASCVD预防策略,考虑到遗传风险,可以提高效率和结果.
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