职业和环境暴露:出版物,疾病和实验模型中的趋势
Omur Sert1, Ozlem Yesil-Celiktas1,2,3
1Department of Bioengineering, Ege University Faculty of Engineering, İzmir, Türkiye.
Thoracic research and practice
|December 4, 2025
概括
对粉和微塑料等环境暴露的研究正在增加,肺纤维化是研究最多的疾病. 目前的研究很大程度上依赖于动物和体外模型,凸显了对先进,与人类相关的器官芯片系统的需求.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 生物医学工程 生物医学工程
背景情况:
- 环境中暴露于二氧化尘,微塑料和一般尘埃对健康构成重大风险.
- 吸入的细颗粒和超细颗粒可以与肺上皮细胞直接相互作用,引发炎症和纤维性反应.
- 呼吸道上皮是重要的防御机制,但容易受到吸入有害物质的伤害.
研究的目的:
- 分析环境暴露 (,微塑料,尘埃) 和相关疾病的研究趋势 (2000-2025年).
- 评估不同实验模型的利用,包括动物模型,体外系统和器官芯片平台.
- 确定研究缺口,并强调需要先进的,与人类相关的模型来研究暴露效应.
主要方法:
- 为了量化有关特定职业暴露和相关疾病的出版物,进行了PubMed搜索 (2000-2025年).
- 实验模型 (transwell,器官在芯片上,体外,体外,动物) 分析了它们的使用频率.
- 用趋势图,条形图和热图编制和可视化数据,以显示暴露-疾病和暴露-模型关系.
主要成果:
- 粉和微塑料的出版趋势显示出显著的增长,特别是在2016年之后的微塑料.
- 肺纤维化是与粉尘和一般粉尘暴露相关的最常被研究的疾病结果.
- 动物模型和传统的体外研究主导着实验方法,而器官芯片平台的使用最小.
结论:
- 对环境暴露的研究兴趣日益增长,但在使用生理学上相关的人类实验系统方面存在重大差距.
- 器官芯片技术为重复人类上皮质屏障和组织特异性反应提供了潜力,但仍未得到充分利用.
- 这些发现强调需要创新的实验模型,如器官芯片,以提高对暴露相关病理生理学的理解,并弥合转化差距.
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