寻找平衡:在调节环境可塑性和记忆力方面,H3K27me3编写器和擦拭器之间的动态相互作用
1School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK.
The New phytologist
|December 4, 2025
概括
植物通过表观遗传基因调节来适应环境变化. 基因组H3氨酸27三甲基化 (H3K27me3) 和其调节剂是应激适应和性的关键.
科学领域:
- 植物生物学 植物生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 环境压力反应环境压力反应
背景情况:
- 植物表现出适应环境波动的可塑性.
- 通过基因组修饰进行表观遗传基因调节,提供了适应性灵活性.
- 基因组H3氨酸27三甲基化 (H3K27me3) 是一个关键的表观遗传标记.
研究的目的:
- 探索H3K27me3写字器和擦拭器在植物应激适应中的作用.
- 突出 H3K27me3 与其他染色体标记的情境依赖调节和相互作用.
- 提供关于H3K27me3功能在增强植物弹性方面的最新观点.
主要方法:
- 对植物中H3K27me3动态现有文献的综述.
- 分析了Polycomb Repressive Complex 2 (写字器) 和 Jumonji 类去甲基酶 (擦除剂) 的作用.
- 在应激响应的位置检查H3K27me3调节.
主要成果:
- H3K27me3调节应激反应基因,有助于适应.
- H3K27me3 写字器和擦拭器在应激反应途径中起到中央调节者的作用.
- H3K27me3与其他染色质修饰之间的相互作用影响了适应性结果.
结论:
- H3K27me3在植物适应过程中发挥着至关重要的作用.
- 了解H3K27me3的动态对于提高植物对环境变化的弹性至关重要.
- 由H3K27me3介导的表观遗传机制对于植物在波动的环境中生存至关重要.
相关概念视频
Spreading of Chromatin Modifications
9.3K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
9.3K
Histone Modification
15.8K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
15.8K
Chromatin Modification in iPS Cells
2.1K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.1K
Position-effect Variegation
7.0K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.0K
Nucleosome Remodeling
10.7K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
10.7K
Inheritance of Chromatin Structures
7.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.2K


