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H₂S 点击交付:响应释放用于胸前大动脉剖析多维治疗

Yunpeng Luo¹, Daquan Wang², Gang Tan²

¹Clinical School of Thoracic, Department of Cardiovascular Surgery, Tianjin Medical University, Tianjin Chest Hospital, Tianjin, P. R. China.

Advanced healthcare materials

|December 4, 2025

概括

一种新型的聚合物PSG12可提供硫化 (H2S),精确用于治疗胸前大动脉剖析 (TAD). 这种向治疗可以保护内皮细胞,并提高TAD小鼠模型的生存率,为这种心血管紧急情况提供了一个有前途的新疗法.

科学领域:

生物材料科学生物材料科学
心血管研究研究心血管研究
药物输送系统药物输送系统

背景情况:

胸前动脉解剖 (TAD) 是一个危及生命的心血管紧急情况,药物治疗有限.
内皮功能障碍和硫化 (H2S) 水平降低是TAD进展的关键因素.
目前的H2S疗法因不受控制的释放和毒性而面临挑战.

研究的目的:

开发一种新型的,可控的硫化 (H2S) 释放聚合物,用于治疗胸前大动脉解剖 (TAD).
在TAD的细胞和动物模型中评估开发的聚合物 (PSG12) 的疗效.

主要方法:

一种对谷氨 (GSH) 敏感的H2S释放聚合物 (PSG12) 用气点击聚合策略进行了合成.
描述了PSG12的H2S释放动力学和药理动力学特征.
评估了PSG12的治疗效果在TNF-α挑战的内皮细胞和BAPN诱导的TAD小鼠模型中.

主要成果:

PSG12表现出可调节和持续的H2S释放,维持治疗性血水平12小时.
在体外,PSG12显著降低了内皮细胞的氧化应激,衰老,亡和炎症,同时保留了细胞外基质.
在体内,PSG12治疗减少了大动脉破裂的发生率,并在TAD小鼠模型中改善了生存率.

结论:

通过多路径协同调节,PSG12有效地恢复内皮细胞平衡.
这种GSH响应的聚合物代表了一个有前途的精密气疗平台,用于管理胸前大动脉剖析.
开发的聚合物为心血管紧急情况的H2S输送提供了可控和有针对性的方法.

关键词:

控制的药物释放控制的药物释放内皮膜屏障保护保护的内皮膜屏障气体点击聚合物的高分子.硫化 (H2S) 是一种硫化.胸前大动脉剖析 (TAD) 是一种切除术.

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