爬行脂肪可以是克罗恩病的预后因素吗?
Naime Demiral1, Fatma Ayça Edis Özdemir2, Fatih Kıvrakoğlu3
1Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Türkiye.
概括
在CT扫描中爬行脂肪 (CF) 可以预测克罗恩氏病的预后. 较高的CF指数值与较高的狭窄风险有关,表明其作为非侵入性标记物的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 克罗恩氏病 (CD) 管理需要准确的预后标记.
- 爬行脂肪 (CF),中肠脂肪的增加,在CD患者中观察到.
- 计算机断层扫描 (CT) 是CD评估的常见成像方式.
研究的目的:
- 评估CT扫描中的爬行脂肪 (CF) 发现是否可以作为预测克罗恩病预后的非侵入性标记.
- 确定CF特征与疾病严重程度,特别是狭窄症之间的关联.
主要方法:
- 对128名克罗恩病患者 (年龄18-70岁) 的CT扫描进行了回顾性分析.
- 患者根据狭窄症分为几组:经过手术,未经手术和没有狭窄症.
- 评估CF指数 (肠表面覆盖面积比率 - BSACR),CF密度和内脏-皮下脂肪比率 (VSFR).
主要成果:
- 与没有狭窄的患者相比,内脏-皮下脂肪比率 (VSFR) 在患有狭窄的患者中显著更高 (0.7 vs 0.4;P = .003).
- 在狭窄症组中,CF指数BSACR显著更高 (27.1%对18.2%;P = .001).
- 在CF指数BSACR值较高时,狭窄的几率大大增加 (OR=17.07对于≥37.5%,OR=184.57对于≥50%).
结论:
- 肺结核指数BSACR是一个有前途的非侵入性放射学标志物,用于预测克罗恩氏病的预后.
- 在CT上CF的发现与严格的疾病相关,有助于预后评估.
- CT评估的爬行脂肪可能有助于识别患有狭窄风险较高的患者.
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