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表达Wnt3a的癌症干细胞损害CD8+TRM功能,导致黑色素瘤免疫疗法抵抗

Julián A Gajón1,2, Angel Juarez-Flores3, Fatima Mendoza-Roldan2

  • 1Posgrado en Ciencias Bioquímicas, Universidad Nacional Autónoma de México, Ciudad de México, México.

Oncoimmunology
|December 4, 2025
PubMed
概括

Wnt通路的激活驱动癌症干细胞,通过损害CD8+T细胞导致黑色素瘤抗PD-1免疫疗法的抵抗. 抑制Wnt信号恢复T细胞功能并逆转抵抗.

关键词:
在CD8+ TRM中使用.这是WNT3a.在Wnt/β-catenin信号传输中.癌症干细胞是癌症干细胞.免疫检查点封锁封锁免疫疗法耐药性 免疫疗法耐药性黑色素瘤是一种黑色素瘤.

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