心力衰竭与保存的喷射分数:当前的见解和新兴的治疗方向
Jeehyun Kim1,2, GwangHyeon Eom1,2, Somy Yoon2,3
1Department of Pharmacology, Chonnam National University Medical School, Hwasun 58128, Korea.
概括
保持喷射分数 (HFpEF) 的心力衰竭在亚洲很常见. 新的治疗方法,如SGLT2抑制剂和GLP-1受体激动剂,对HFpEF患者来说是有前途的,特别是考虑到亚洲人口的独特特征.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭占亚洲心力衰竭病例的一半以上,具有显著的一年住院和死亡率.
- 亚洲HFpEF患者经常出现高血压和糖尿病,但通常的体重指数低于西方队列.
研究的目的:
- 审查目前和新兴的HFpEF治疗方法.
- 突出亚洲人群中HFpEF独特的临床和病理生理特征.
- 讨论该地区未来治疗发展的考虑因素.
主要方法:
- 对HFpEF治疗的里程碑式临床试验 (EMPEROR保存,DELIVER) 的审查.
- 对HFpEF中葡萄糖类-1受体激动剂的最近研究的分析.
- 综合比较亚洲和西方HFpEF表型的数据.
主要成果:
- -葡萄糖共运输体2抑制剂 (例如,empagliflozin,dapagliflozin) 已在减少HFpEF心血管事件和住院治疗方面表现出有效性.
- 类似葡萄糖-1受体激动剂显示出改善功能能力和症状的潜力,特别是在与肥胖相关的HFpEF中.
- 在亚洲和西方人群之间,HFpEF的临床表现和潜在因素存在显著差异.
结论:
- SGLT2 抑制剂代表了HFpEF的关键治疗进展.
- 像GLP-1受体激动剂这样的新兴药物为管理HFpEF提供了新的途径,特别是在特定的患者亚组中.
- 根据亚洲HFpEF患者的独特特征量身定制治疗策略对于优化治疗结果至关重要.
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