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Updated: Jun 14, 2026

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通过比较类人猿,我们发现了人类特异性的ZEB2在神经发育中的作用

Jeong-Eun Lee1,2, Vladimir M Jovanovic1,3, Amanda Jager Fonseca1

  • 1Human Biology and Primate Evolution Group, Institute of Biology, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany.

Molecular biology and evolution
|December 4, 2025
PubMed
概括

人类ZEB2转录因子独特地调节了比其他类人猿更多的神经系统基因. 这种ZEB2中的调节分歧有助于人类进化特征和表型差异.

关键词:
在ZEB2中,它是ZEB2.比较的转录组学 进行比较基因调节 基因调节 基因调节人类特异性的人类特异性.它们是灵长类的灵长类.

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Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...