卡德林-18和孕前:一个具有预后价值的新生物标志物在第二个三个月?
Neset Gumusburun1, Sebati Sinan Urkmez2, Yesim Civil Urkmez3
1Department of Obstetrics and Gynecology, Istanbul Aydın University Faculty of Medicine, Istanbul, Turkiye.
The journal of obstetrics and gynaecology research
|December 4, 2025
概括
在孕前患者中,血清卡德林-18水平显著更高. 增加的卡德林-18显示出作为预测子宫前,特别是早期发病形式的生物标志物的潜力.
科学领域:
- 产科和妇科 产科和妇科
- 生物标志物发现发现
- 怀孕并发症 怀孕并发症
背景情况:
- 孕前是一种严重的妊娠并发症,影响母亲和胎儿的健康.
- 卡德林与热囊细胞的发育和胎盘有关,这表明它在孕前的发病过程中发挥了作用.
研究的目的:
- 为了研究血清中cadherin-18水平对孕前的预测潜力.
- 评估cadherin-18作为怀孕早期的生物标志物.
主要方法:
- 追溯病例对照研究,比较第二 trimester早期怀孕的血清cadherin-18水平.
- 包括170名孕妇 (85名孕前症,85名健康对照).
主要成果:
- 与对照人群相比,患有孕前的妇女的血清卡德林-18水平显著升高.
- 切断值为1015.9 pg/mL显示了57.6%的灵敏度和94.1%的特异性,用于诊断妊娠前.
- 超过1302.5ppg/mL的水平显示了85.0%的灵敏度和98.5%的特异性,用于预测早期发病的先兆子.
结论:
- 卡德林-18水平与孕前显著相关.
- 卡德林-18作为预测性生化标志物对子宫前,特别是早期发病病例显示出希望.
更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
1.2K
10:44A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
Published on: June 2, 2019
6.2K
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
521
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
521
01:25Structure of Cadherins
4.6K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
4.6K