在帕金森病的脑下核深度大脑刺激期间的过渡性外科手术攻击性行为
Paulo Cataniag1,2, Jed Noel Ong1, Rosalia Teleg1,3,4
1Movement Disorders Clinic, MakatiMed Institute of Neurological, Neurosurgical and Behavioral Sciences, Makati City, Philippines.
Asian journal of neurosurgery
|December 4, 2025
概括
对帕金森病 (PD) 的深度大脑刺激很少会在手术期间引起急性精神症状. 仔细的手术前评估和手术内监测对于管理这些罕见但严重的并发症至关重要.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 脑下核的深度大脑刺激 (STN-DBS) 是晚期帕金森病 (PD) 的首要治疗方法.
- 虽然有效,但STN-DBS可能与外科手术期间的神经精神疾病并发症有关,尽管急性手术期间精神疾病事件很少发生.
- 术前查方案旨在减轻风险,但仍可能出现不可预见的精神反应.
研究的目的:
- 在帕金森病的STN-DBS手术中报告在手术内微刺激期间发生的一种罕见的急性攻击性行为.
- 突出神经解剖学理解和手术前精神病学评估在STN-DBS程序中的重要性.
- 讨论STN-DBS期间手术内精神病并发症的管理.
主要方法:
- 一个57岁的患有帕金森病的女性患者的病例报告,接受STN-DBS.
- 在微刺激下丘脑核过程中,对突然出现的侵略性行为进行手术期间的观察.
- 调整精神病症状的DBS位和药理管理.
主要成果:
- 在左STN微刺激过程中,患者表现出急性攻击性行为.
- 在重新定位DBS后改善的行为变化导致更侧向的位置.
- 精神症状在七天内随着提氨酸治疗而消失,在随访期间没有复发.
结论:
- 这一案例强调了深入了解STN神经解剖学及其在DBS手术中的临床含义的必要性.
- 综合性手术前精神病学评估对于预测和管理潜在的不良事件至关重要.
- 术内调整和药理干预可以有效地管理STN-DBS期间的急性精神并发症.
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