联合或连续的特里巴胺治疗骨质疏松症在denosumab-users:现实世界骨矿物质密度结果
Shejil Kumar1,2,3, Courtney Streeter2, Michelle M McDonald2,4,5
1Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.
Bone reports
|December 4, 2025
概括
在已经服用Dmab的骨质疏松症患者中,将德诺苏马布 (Dmab) 与特里巴 (TPTD) 结合使用显著增加腰椎骨矿物质密度 (BMD). 顺序治疗没有显示出显著的BMD增长,这表明组合疗法是一个有前途的骨质合成药策略.
科学领域:
- 内分泌学 在内分泌学.
- 整形外科 整形外科 整形外科
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 对于接受德诺苏马布 (Dmab) 治疗的患者来说,最佳的骨代谢策略尚不清楚.
- 之前的研究表明,代诺苏马布/特里巴拉提德 (TPTD) 组合疗法在未经治疗的患者中增加了骨矿物质密度 (BMD).
- 在已有Dmab治疗的患者中,Dmab/TPTD组合的BMD结局尚未研究.
研究的目的:
- 为了研究结合TPTD与正在进行的Dmab与已建立Dmab治疗的患者的顺序Dmab和TPTD的BMD结果.
主要方法:
- 骨质疏松症患者在2013-2023年期间接受Dmab并随后接受TPTD (≥12个月) 的回顾性审查.
- 患者被分为"组合" (TPTD添加到正在进行的Dmab) 或"序列" (Dmab在TPTD期间被保留) 组.
- 在TPTD治疗期间的BMD变化通过DXA扫描进行评估.
主要成果:
- 组合组显示显著的腰椎骨质量增长 (+9.8%,p=0.004),而序列组显示没有显著的变化 (+3.5%,p=0.107).
- 与测序组相比,在组合组中,腰椎骨质量增长显著更大 (p=0.039).
- 在两组中,部和大腿部部的BMD保持稳定.
结论:
- 在已使用Dmab的患者中,使用登苏马布和特里巴拉提德的联合治疗与显著的腰椎骨质量增加有关.
- 这项回顾性研究表明,Dmab/TPTD组合可能是有效的骨质合成药策略.
- 有必要进行前性受控研究来证实这些发现并优化治疗策略.
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