血清作为心血管疾病的危险因素在2型糖尿病患者中
Dajana Katičić1, Josipa Josipović1, Marko Lucijanić2
1Division of Nephrology and Dialysis, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
高正常血清水平与2型糖尿病患者心血管事件增加有关. 即使含量略有增加,也会显著增加心血管事件的风险,而不依赖于其他风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 对于生理功能至关重要.
- 高与心血管疾病和死亡率有关.
- 高正常在2型糖尿病心血管疾病发病率中的作用需要进一步研究.
研究的目的:
- 研究2型糖尿病患者高正常血清含量与心血管疾病之间的关联.
- 为了确定血清含量是否可以预测这个人群中的心血管事件.
主要方法:
- 一项涉及280名2型糖尿病患者 (140名患有心血管事件,140名没有) 的病例控制研究.
- 收集了禁食实验室值,病史和检查结果.
- 使用单变量和多变量逻辑回归分析.
主要成果:
- 患有心血管事件的患者的血清含量显著更高 (AUC 0.591,p=0.008).
- 单变量分析显示,血清含量每增加1mmol/L,心血管事件的概率增加7.4倍 (OR7.1849,p=0.0057).
- 多变量分析证实了血清与心血管事件的相关性 (OR 16.6,p=0.0016),独立于其他危险因素.
结论:
- 高正常血清水平与2型糖尿病患者的心血管疾病有显著的相关性.
- 血清是该人群中心血管事件的独立预测因子.
- 监测水平可能有助于评估2型糖尿病患者的心血管风险.
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