在前期支臂治疗后,IMRT和手术后,在口舌状细胞癌中比较吞功能
Kai Ping Ong1, Muhamad Yusri Musa2, Irfan Mohamad1
1Otorhinolaryngology-Head & Neck Surgery, School of Medical Science, Universiti Sains Malaysia (USM), 16150, Kubang Kerian, Kelantan, Malaysia.
Journal of contemporary brachytherapy
|December 4, 2025
概括
接受HyBIRT支臂疗法治疗的口腔舌状细胞癌 (OTSCC) 患者的吞功能比接受手术的患者更好. HyBIRT为OTSCC管理和吞保存提供了一个有希望的器官保存替代品.
科学领域:
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 辐射瘤学 辐射瘤学
背景情况:
- 口腔舌状细胞癌 (OTSCC) 是一种普遍存在的头癌.
- 手术和支臂疗法都是OTSCC的确立治疗方式.
- 这些治疗对吞功能的比较影响需要进一步阐明.
研究的目的:
- 分析手术与手臂治疗对OTSCC患者吞结果的差异性影响.
- 为了比较用HyBIRT支臂疗法治疗的患者和用手术治疗的患者之间的吞功能.
主要方法:
- 一项涉及30名经组织学确认的OTSCC患者 (14名HyBIRT,16名手术) 的横截面研究.
- 患者选择标准包括放射性完整反应和治疗后至少6个月的无病状态.
- 使用吞能力量表 (SCS),马来式饮食评估工具-10 (Malay EAT-10) 和透吸收量表 (PAS) 来评估吞功能.
主要成果:
- 与手术组相比,HyBIRT组表现出更好的吞能力 (SCS平均值6.5与4.7) 和更好的饮食生活质量 (马来语EAT-10中位数5与22).
- 透-吸收量表 (PAS) 的得分在HyBIRT组显著较低 (中位数为1比2),表明吸收较少 (p = 0.02).
- 所有吞评估都显示了统计学上显著的差异,有利于HyBIRT治疗.
结论:
- 器官保存HyBIRT技术是OTSCC管理的一个有希望的替代方案.
- 与传统手术相比,HyBIRT在保护吞功能方面具有显著的优势.
- 建议进行进一步的大规模分层研究,并进行延长的随访,以验证这些发现.
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