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转激素受体在促进甲状腺癌中PANoptosis的作用

Shungao Ma¹, Zhiqiang Ma¹, Jingwei Shen¹

¹Department of Clinical Laboratory, Dali Bai Autonomous Prefecture People's Hospital, Dali, Yunnan 671000, P.R. China.

Oncology letters

|December 4, 2025

概括

转移素受体 (TFRC) 在甲状腺癌 (TC) 中促进PANoptosis,一种细胞死亡形式. 在TC中TFRC的下调表明其作为预后生物标志物和治疗点的作用,用于增强细胞死亡.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
分子生物学分子生物学

背景情况:

泛亡是一种新兴的受调细胞死亡 (RCD) 途径,涉及亡,亡和热亡.
转激素受体 (TFRC) 参与各种RCD,并作为甲状腺癌 (TC) 的抑制剂.

研究的目的:

研究TFRC在TC中PANoptosis中的作用.
阐明TFRC对TC中PANoptosis的影响的分子机制.

主要方法:

对TCGA-THCA数据集的生物信息学分析,以识别与PANoptosis标记物 (ZBP-1,AIM2) 相关的基因.
细胞测试 (PI/Calcein-AM,YO-PRO-1/PI染色,西部涂抹) 来评估TFRC对TC细胞死亡的影响.
使用mRNA测序 (mRNA-seq) 来识别与TFRC相关的差异表达mRNA,并构建蛋白质-蛋白质相互作用网络.

主要成果:

TFRC被确定为TC的预后生物标志物,在瘤组织和细胞中显著下调.
过度表达TFRC促进了烧灭,灭和灭,减少了可活的TC细胞,并调节了关键蛋白表达 (caspases,MLKL,RIPK3).
TFRC与CD34,LDHA和LDLR相互作用,这些在TFRC敲击时被下调,这表明它们参与了TFRC介导的PANoptosis.

结论:

在TC中促进PANoptosis方面,TFRC起着至关重要的作用.
TFRC可以通过与CD34,LDHA和LDLR的相互作用来发挥其功能.
在TC中,TFRC代表了调节细胞死亡途径的潜在治疗标.

关键词:

这就是PANoptosis.一个RNA序列的RNA序列.生物信息学是一种生物信息学.甲状腺癌是一种癌症.转移素受体的受体是转移素的受体.

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