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Updated: Jan 9, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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Published on: January 13, 2013

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整体合成的 ent - 有效西林A和有效西林B

Huixing Gu1, Ziyi Li1, Xinwei Zhang2

  • 1Hebei Technology Innovation Center for Energy Conversion Materials and Devices, College of Chemistry and Material Science, Hebei Normal University No. 20, East Road of Nan Er Huan Shijiazhuang 050024 China zhangwei@hebtu.edu.cn.

Chemical science
|December 4, 2025
PubMed
概括

研究人员实现了第一个不对称的 aogacillin B 和 ent-aogacillin A 的总合成,这些化合物是克服MRSA. arbekacin 耐药性的关键化合物. 这一突破利用了一种新的策略,涉及基C-H氧化和一电位序列醇反应和乳化.

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