在后急性COVID-19综合征中计算机断层扫描的变化:系统性审查和元分析
Tatiane Peroba Araújo1,2,3, Glécia Virgolino da Silva Luz2,4, Marília Miranda Forte Gomes2
1Secretaria de Saúde do Distrito Federal, Brasília, DF, Brazil.
Radiologia brasileira
|December 4, 2025
概括
许多COVID-19幸存者在诊断几个月后的CT扫描上有持续的肺部异常. 虽然整体肺部变化随着时间的推移而减少,但纤维化患病率保持稳定,与最初的疾病严重程度相关.
科学领域:
- 放射学 放射学是一门学科.
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致长期呼吸道并发症.
- 计算机断层扫描 (CT) 上的残留肺部变化是COVID-19后患者的一个担忧.
研究的目的:
- 为了估计COVID-19后CT扫描中残留的肺膜变化的患病率.
- 为了将这些变化与疾病急性阶段的严重程度相关联.
主要方法:
- 观察性研究的系统审查和元分析.
- 包括在诊断后3,6个月和12个月评估的中度至危急COVID-19的成年患者.
- 搜索了14个数据库,查找2020年1月至2024年1月期间发表的研究,选择了44项主要研究.
主要成果:
- 改变CT扫描的患病率为3个月后69.0%,6个月后62.0%,诊断后12个月后54.0%.
- 在3个月后的22%CT扫描中存在肺纤维化迹象的变化,并没有随着时间的推移而减少.
- 没有发现急性阶段严重程度和整体持续性CT变化之间的一般相关性,但3个月的纤维化与急性严重程度相关.
结论:
- 显著比例的COVID-19幸存者在CT扫描上表现出持续的肺部异常.
- 肺纤维化患病率在COVID-19后保持不变,并与最初的疾病严重程度有关.
- 对于COVID-19幸存者来说,长期CT监测可能是必要的,特别是那些最初患有严重疾病的人.
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