在2型糖尿病中,运动后的免疫炎症改善与基线胰岛素抵抗有关
Wei Cheng1, Kai Guo1, Xuelian Zhang1
1Department of Endocrinology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
运动改善了2型糖尿病的代谢健康,但严重的胰岛素抵抗 (IR) 限制了对身体组成和免疫标志物的益处. 无论IR水平如何,血糖水平的改善都会发生.
科学领域:
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
背景情况:
- 2型糖尿病 (T2DM) 的特点是胰岛素抵抗 (IR).
- 运动干预对于管理T2DM至关重要,影响代谢和炎症概况.
- 基线IR严重程度对运动诱导的免疫炎症变化的影响尚未完全理解.
研究的目的:
- 调查基线胰岛素抵抗 (IR) 如何影响T2DM患者的全身免疫炎症指数 (SII) 和代谢参数的运动诱导变化.
- 根据IR水平对T2DM患者进行分层,并评估对联合炼计划的差异反应.
主要方法:
- 55名T2DM患者根据禁食C水平分为低,中和高IR组.
- 参与者完成了为期4周的中等强度有氧和阻力运动计划.
- 用ANCOVA和等级回归分析了SII (计算为中性粒细胞×血小板/淋巴细胞),人体测量和葡萄脂标记物的变化.
主要成果:
- 低/中等IR患者的体重,BMI和体脂百分比显著降低;高IR组没有.
- 在低IR组中SII下降,但在高IR组中由于中性粒细胞升高而增加.
- 在所有组中,禁食葡萄糖和HbA1c均有所改善,高IR组的益处与减肥或抗炎作用无关.
- 基线C-水平独立预测SII的增加.
结论:
- 在T2DM中,严重的基线胰岛素抵抗减弱了运动诱导的SII和身体组成的改善.
- 在T2DM中,运动对血糖的益处与基线IR严重程度无关.
- 对于T2DM的运动处方应根据个人IR水平进行分层,以获得最佳的结果.
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