与衰老相关的CD55+纤维细胞促进慢性炎症和在肉症中ECM失调
Xianfei Xie1,2, Jiawen Zhao3, Tong Wu3
1Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Journal of inflammation research
|December 4, 2025
概括
研究人员确定了一种特定的纤维细胞亚型 (CD55+FB_4) 驱动在肉肌 (与年龄相关的肌肉损失) 肌肉中的炎症和纤维化. 准这些细胞可能为与年龄相关的肌肉退化提供新的治疗方法.
科学领域:
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
- 肌肉生理学 肌肉生理学
背景情况:
- 标志着与年龄相关的肌肉质量和功能丧失的萨尔科佩尼亚,显著导致老年人的脆弱和残疾.
- 纤维细胞,除了ECM的生产,在炎症,纤维化和免疫反应中发挥积极作用.
- 在sarcopenic肌肉中纤维细胞亚型的特定功能和异质性尚未得到充分理解.
研究的目的:
- 系统地描述人类骨肌中的纤维细胞群.
- 阐明纤维细胞异质性在与年龄相关的肌肉退化和肉症中的作用.
主要方法:
- 采用了整合性的多omics方法,将单核RNA测序 (snRNA-seq) 结合起来.
- 纳入非目标代谢和组织学分析,以进行全面的表征.
- 专注于识别不同的纤维细胞亚型及其在骨肌肉中的功能特征.
主要成果:
- 确定了几种不同的纤维细胞亚型,CD55+纤维细胞 (FB_4) 是老年肌肉中促炎和纤维细胞微环境的主要贡献者.
- 在FB_4细胞中,NF-κB信号被激活,糖溶性代谢增强,氧化应激增加.
- FB_4活性与衰老相关的分泌表型 (SASP) 和增加的免疫细胞透,以及增加的TGF-β1和TLR4表达相关.
结论:
- CD55+ FB_4细胞被确定为慢性炎症和肌肉衰老中的细胞外矩阵重塑的关键驱动因素.
- 向纤维细胞介导炎症和纤维化是一种潜在的治疗策略.
- 这种多学科的方法为纤维细胞异质性提供了新的见解,并为与年龄相关的肌肉疾病的未来干预提供了一个框架.
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