评估自主神经系统作为多发性硬化症患者睡眠质量驱动者的作用:观察性研究
Max Moebus1, Marc Hilty2, Pietro Oldrati2
1Department of Computer Science Eidgenössische Technische Hochschule Zürich (ETH Zurich) Zurich Switzerland.
JMIR neurotechnology
|December 4, 2025
概括
对于多发性硬化症 (MS) 患者来说,白天的压力和夜间的压力反应显著损害了睡眠质量,比健康个体更严重. 管理压力对于改善MS患者的睡眠至关重要.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 睡眠质量低下是多发性硬化症 (MS) 的普遍问题,严重影响患者的生活质量.
- 对于睡眠调节至关重要的自主神经系统 (ANS) 在MS患者中经常受到损害.
- 在MS中,ANS功能与自我报告的睡眠质量之间的确切关系尚未得到充分理解.
研究的目的:
- 量化评估自主神经系统 (ANS) 和多发性硬化症 (MS) 对感知睡眠质量的影响.
- 调查睡眠期间生理应激反应如何影响MS患者的睡眠质量,与对照人群相比.
主要方法:
- 利用可穿戴传感器和智能手机应用程序,在两周内从77名参与者 (53名多发性硬化患者,24名对照) 收集了20700小时的数据.
- 持续监测心率 (HR) 和每秒HR变化,以及压力水平,活动和感知睡眠质量.
- 收集了关于年龄和性别的数据,以实现强大的群组匹配.
主要成果:
- 在MS患者和对照人群中,减少HR变化和睡眠期间增加运动与感知睡眠质量较低相关.
- 睡眠期间激活的应激反应 (高同情,低寄同情活动) 显著降低了睡眠质量,在多发性硬化症患者中效果更为明显.
- 增加的白天压力水平不成比例地影响了MS患者的睡眠质量,与睡眠期间最小的HR负相关,并可能破坏日常生活.
- 患有更严重疾病进展的MS患者报告睡眠质量较差.
结论:
- 白天的压力和睡眠期间激活的压力反应是MS患者睡眠质量的关键决定因素,比健康个体更重要.
- 减少压力因素可能是改善MS患者睡眠质量的关键策略,同时确保足够的睡眠时间.
- 随着多发性硬化症疾病进展的严重程度的增加,睡眠质量通常会下降.
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