医疗保健中的数字双胞胎:全面审查和未来的方向
Hamid Khoshfekr Rudsari1, Becky Tseng1, Hongxu Zhu1
1Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Frontiers in digital health
|December 4, 2025
概括
数字双胞胎 (DTs) 正在通过实现个性化医疗和优化治疗来彻底改变医疗保健. 虽然在心律失常和神经退行性疾病预测等领域表现出临床成功,但在数据集成和可扩展性方面的挑战需要解决,以实现更广泛的临床转化.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 数字健康数字健康
背景情况:
- 数字双胞胎 (DT) 技术为医疗保健提供了变革性的潜力.
- DTs使个性化医疗,治疗优化和在生理层面的疾病预防成为可能.
研究的目的:
- 审查医疗保健中数字双胞胎的现状.
- 分析它们的实施,方法,应用,挑战和机会.
主要方法:
- 在细胞到全身系统之间对DT发展的系统性审查.
- 对各种生理系统 (心血管,神经等) 的技术框架的分析. ) 的情况.
- 检查数据采集,建模方法和人工智能技术.
主要成果:
- 显著的成就包括人口规模的心脏建模,减少心房的复发,改善放射治疗计划,先进的肝脏再生建模和增强的糖尿病管理.
- DT已经显示出临床成功,包括超过13%的心律不整复发率降低和97%的精度的神经退行性疾病预测.
结论:
- 医疗保健DT表现出了显著的临床成功,但需要解决更广泛的临床翻译的挑战.
- 关键的挑战包括数据集成,计算可扩展性,数字公平性和强大的验证框架.
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