基于肠道微生物群的生物标志物用于精确的亚型分类和对胆汁和超脂性急性胰腺炎的机制理解
Xinyu Deng1,2, Xueqian Wu1, Ruobing Wang1
1Department of Laboratory Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Frontiers in microbiology
|December 4, 2025
概括
急性胰腺炎 (AP) 亚型,胆汁性胰腺炎 (BAP) 和高脂性胰腺炎 (HLAP) 呈现出明显的肠道微生物群变化. 这些微生物变化与疾病严重程度和功能障碍相关,为精准医学提供了洞察力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 急性胰腺炎 (AP) 是一种严重的炎症状况,肠道微生物群的作用尚不清楚.
- 像胆汁AP (BAP) 和高脂血型AP (HLAP) 这样的病因亚型可能具有独特的微生物特征.
研究的目的:
- 为了研究BAP和HLAP中的特定病因的肠道微生物群概况.
- 为了将这些特征与疾病严重程度和代谢功能障碍相关联.
主要方法:
- 横截面研究分析了20名BAP患者,20名HLAP患者和20名健康对照 (HC) 的便样本的16S rRNA基因测序.
- 微生物多样性,分类学和功能基因的生物信息分析.
- 相关性分析和机器学习模型 (RF,后勤回归) 用于生物标志物发现.
主要成果:
- 两组AP表现出微生物多样性的减少与对照组相比;HLAP显示出更严重的失生症.
- 在HLAP患者中,炎症促成的种类增加 (例如, *Escherichia-Shigella*, *Collinsella*) 和有益的种类减少 (例如, *Faecalibacterium*, *Bifidobacterium*).
- 在AP患者中观察到受损的短链脂肪酸 (SCFA) 生物合成基因;多种小组改善了亚型诊断.
结论:
- BAP和HLAP患者表现出明显的肠道微生物群特征,其特点是失生症和功能障碍.
- 这些发现将肠道微生物组成与AP病理生理学联系起来,支持针对微生物的精准医学.
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